Wednesday, February 29, 2012

Redefinition of Starch With Maxxis ATV Tires | Living-Lab

Maxxis is a global leader in the tire industry. Founded nearly 40 years, these bands extremely pleased with his company millions of customers quality and innovative design. Anyone with a car, truck, motorcycle or other vehicle driven wheels with Maxxis has vowed never to use another brand. These tires are very cheap and can be purchased online.

Operation on more than 170 countries Maxxis ATV tires are designed to adapt to any terrain. They are made of special high quality rubber, and the thick outer grooves on their surface, making them excellent grip. You can access the site of the worst race ? but Maxxis ATV tires will ensure that the risk of slippage is minimized. This ATV is for all-terrain tires that are designed to even the toughest surfaces developed as one of the Rocky Mountains to resist.

Guaranteeing dimming possibilities this connection that in the end, no matter how hard the strong shock horribly wrong, you will not be able to get the most out of the shock to feel. Sun Maxxis ATV ensure a smooth and comfortable ride to their proud owners. You can now easily climb over hills, and may even fall almost vertical slopes ? Maxxis ATV tires as long as you have and your own natural talent and experience you can be sure that you are safe.

These bands are especially useful for people working in adventure sports, or who commute on rough terrain due to the fact that they have to live there. The people in the logistics and transport industry in particular, who are able goods as quickly as possible to be a part of the world must feel to be transported, so the advantage that Maxxis ATV tires on their vehicles. This will ensure that they are able to safely transport the goods, with minimal damage, and the maximum speed, making a higher return on investment. Maxxis ATV tires provide the words strong and robust, a whole new meaning and is therefore a revolution in the tire industry.

This entry was posted in ATV. Bookmark the permalink.

Source: http://www.living-lab.org/646/redefinition-of-starch-with-maxxis-atv-tires

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Hands On With One X, HTC?s Newest Flagship Android Phone

HTC ruled the roost in the early days of Android, but has since been losing ground to Samsung. Can the Taiwanese manufacturer bring it all back with the One Series? We examined the One X from every angle to find out.

Source: http://feedproxy.google.com/~r/GearFactor/~3/SYG_zheqXik/

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Denver Auto Car Accident Attorney Lawyer ? Starting A vehicle ...

[unable to retrieve full-text content]For a Net-based car or truck repair guidebook. You can begin the direct business on the web. A auto repair direct business on line covers every types of vehicle, from it is make into the model. Its an essential element of a ...

Source: http://www.kimdoo.info/2012/02/28/starting-a-vehicle-repair-internet-business-in-new-mexico/

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How To Choose A Financial Adviser - NASDAQ Investing

The following article will help you make the all the important decisions of how to choose a financial adviser you can trust.

There are 3 easy steps for choosing a financial planner in Australia.

Step 1 ? Understand Your Advice Needs

Not all financial advisers provide all types of financial advice. Some advisers are experts in wealth building strategies, other work only in personal protection insurance.

Therefore, you must choose a financial adviser who?s a match for the specific sort of financial advice you need.

The most common areas of specialisation are:

* Personal Protection Advice

* Wealth building and cash-flow management

* Advice for retirees or people looking to retire

* Self-Managed Superannuation Funds

Financial planners with many years of diverse experience may have knowledge in one, many or all of these advice areas. However, most are not experts in every area of advice because different types of advice require knowledge of the different strategies, legislation and loop-holes. That?s why it?s critical to choose a financial adviser who specialises in the type of advice you require.

Step 2 ? 5 Different Way To Choose A Financial Planner

Now that you understand the type of advice you require you can start searching for a financial planner to match your advice needs. Here are five different ways to choose a financial planner.

1. Ask Your Existing Service Providers

2. Ask A Friend

3. Contact Professional Associations

4. Conduct A Specific Search Engine Search

5. Use The Find A Financial Planner Matching Service

Let?s look at each of these options in more detail.

1. Ask Your Professional Service Providers

Your existing accountant, finance broker or general insurance consultant may be able to help you choose a financial planner. Be sure to explain the type of advice you require so they can refer you to a specialist financial planner.

One pitfall with this approach is that many finance companies also own financial products and may refer you to one of their internal planners who may only recommend their internal products. Also be cautious if the referrer will receive a referral fee for connecting you with a financial planner. If this is the case, then the referral may be in their best interest and not yours.

2. Ask A Friend or Family Member

Often you will find that friends or family members in a like situation have received financial advice. If so than ask about their experience, were they satisfied with the advice received?

Keep in mind that not all financial advisers specialise in all types of advice, so if it is insurance advice you are after it may not be sensible to ask a retiree for a referral to see their retirement adviser, and so on.

3. Contact Professional Organisations

There are several professional associations who can assist you to find a financial planner from their member database.

* Association of Independent Financial Advisers

* Australian Financial Advisers Association

* Financial Planning Client Advocate

* Financial Planning Association

Professional organisations like these can only refer you to a financial adviser on their member base.

4. Specific Google Search

Try conducting a specific internet search. Include in your search the advice type and a locations, for example, ?Investment Advice Brisbane?. Keep in mind that there are no third party recommendations with this method, as with all the other methods discussed in this article and this is the biggest risk.

5. Use Our Online Matching Service

Want a trustworthy hassle free way to be matched with a specialist financial adviser? The Find A Financial Planner websites is a free service designed to match you based on the type of advice you require and your location with a financial adviser that best meets your needs.

Another benefit of this matching service is that the financial planners need to pass an accreditation by the Financial Planning Client Advocate (FPCA) before they can be listed, which means you get an extra layer of security.

Step 3 ? Qualify Your Financial Planner

When searching for a financial adviser on FindAFinancialPlanner.com.au you know your adviser is FPCA approved, they have had background checks and an accreditation process to guarantee that they meet our high standards.

If you choose to go it alone, the following are some tips to help you qualify the financial planner you choose.

1. Check They?re Licensed ? In Australia, financial planners must hold, or be employed by a business that holds an Australian Financial Services (AFS) licence.

2. Request A Financial Services Guide (FSG) ? A Financial Service Guide (FSG) outlines the services offered, fees involved and what to do in the unfortunate event of a complaints. Obtaining a copy of the FSG which will help you assess a financial planner.

3. What Are The Fees & How Are They Charged? - Before you proceed with any advice, make sure you understand exactly what the fees are and how they will be charged?

4. Who?s Backing The Advice ? Who?s behind the advice if something goes wrong? Do they hold insurance? Are there any ownership conflicts of interest? A financial planning firm can be owned by or licensed by a financial institutions, fund managers or life insurance company. This can lead to conflicts of interest if the adviser is limited to recommending only that companies products.

The Financial Planning Client Advocate (FPCA) can help you when choosing a financial planner. Simply visit the FPCA?s find a financial adviser website to be matched with a finanical planner based on your location and advice needs.

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Source: http://nasdaqtradingnews.com/2012/02/28/how-to-choose-a-financial-adviser/

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Tuesday, February 28, 2012

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Source: http://virtualblackswanmarketing.com/?p=9042

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Obama to speak at UAW conference (AP)

[unable to retrieve full-text content]AP - President Barack Obama has only one public event on his schedule Tuesday, a speech at a United Auto Workers conference in Washington.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20120228/ap_on_go_pr_wh/us_obama_preview

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howielindsey: Full story on #Louisville's newest 2013 football commit: @delaml21 http://t.co/VsA4a5MM @RivalsCNee @KeithRIVALS

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Monday, February 27, 2012

Get The Coping Skills Needed To Deal With Major Stress In Your ...

New Health And Fitness.Org - Health Information You Can Use

Some of the most typical triggers of stress include finances, family, work issues and interpersonal relationships. You will not be able to avoid all sources of stress. How do you develop successful strategies when stress is threatening to overwhelm you? The following article addresses that question, and provides some helpful advice.

Some individuals become substance abusers in an effort to control their stress. Unfortunately, the temporary relief these substances may bring can lead to a denial or evasion of the underlying causes of the stress that is being felt. However, drugs and alcohol are never an appropriate solution. In fact, these substances will only make your life more complicated and stressful in the long run.

When you feel extra stressed out, try to focus on things that you enjoy in life. Positive thinking is beneficial for relaxation and stress relief.

If you have a significant other, spend time with your loved one and go out to a romantic dinner by candle light This will put you in a situation you enjoy, which will relax you and alleviate your stress.

A great stress reliever is focusing on an image that soothes the eyes and mind. Your brain starts to relax when it receives visual stimuli in the form of pleasant images. Some examples include images of serene landscapes such as mountains, or pleasant objects such as flowers. If you don?t have something visual to look at, then close your eyes and envision calming, peaceful settings. You can help your body relax within minutes as you visualize these soothing images in your mind.

Getting a pet can help you with stress management. Studies have shown that petting a cute animal reduces stress levels in just a few minutes.

Regular massage therapy can do a great deal to reduce your stress level. Massages are wonderful, and make you feel relaxed after a long and stressful day. Your sore, aching muscles will be soothed by a massage, and your mind will be rid of those anxiety producing worries.

If you?re feeling overly stressed, take time to stop and socialize with family or friends. Getting together with loved ones to share some laughs and good conversation can often be just the ticket for relieving stress and reducing tension. Social interaction can take many forms, including a nice meal together, watching a film, or engaging in skating or bowling.

If your life is stressful, add exercise to your daily routine. Everyone can experience a better mood if they just go for a walk. Consistent small changes add up to big differences in the quality of life.

Planning ahead is a good way to reduce stress. This will help you focus on what you are doing and not on stress. Make plans to go out with friends or see a movie.

One easy and effective way to reduce your stress is to enjoy a long, hot bath. A few drops of essential oils, or a fizzing bath bomb will make the experience all the more luxurious. Furthermore, you can use this time to listen to relaxing music or read a book. This soak is a wonderful way to shut off the mind for a little while, and to just rest while allowing the stress to dissolve away.

Another stress reducer can be the use of visual imagery. By visualizing calmness, you can reduce the anxiousness you are feeling. This is reported to prove quite effective. For example, while in a warm shower, imagine that you are out by the pool in the sun relaxing, and allow this to eliminate all your stress. Just closing your eyes and spending a few seconds imagining a place of calm and relaxation should work.

Push your wall as if it were a football sleigh to release some stress. This forceful stretching will work tension out of your body and take your focus off of whatever is causing you stress.

For a easy trick to reducing stress, pick up some spearmint or lavender oil. Whenever you find that you?re becoming stressed, put a dab of the oil on your neck and on the underside of your wrists. A small thing such as this can greatly impact your stress level. Why not give it a try?

Even the most innocent-seeming activities may actually be contributing to your feelings of stress. Playing video games may seem like a great way to relax and have fun, but spending hours a day on these games means that you won?t have enough time to do everything else that you need to do. You are spending valuable time that could be used to get a sufficient amount of sleep, or eat a healthy meal.

If you find yourself frequently being irritated by the same, unavoidable things, try self-hypnosis. There are people all across the world whom have had their lives helped or changed, thanks to the power of self-hypnosis.

Take some time to meditate. This is a great way to relax both your body and mind. If you will meditate regularly, you will feel more relaxed going through your days. This also helps to keep your stress in check, even when you are in tense situations.

Everybody has a way to cope, and you should create a way to manage your stress. Any coping mechanisms you have should be deliberately employed, and a good one is repetition of affirmations anytime you feel stress setting in. By helping yourself take a more positive outlook at situations, you?ll be able to release some of the stress that can build up otherwise.

A stressful day can be alleviated by something as simple as a cup of soothing tea, such as chamomile tea. Drinking chamomile tea will relax you, get rid of your headaches, and make it easier to get a good night?s sleep. Chamomile?s relaxing herbal properties, along with the warmth of the hot liquid, can offer your body a great deal of relaxation.

There are many things in life we cannot change; however, there are quite a few we can and should change. Use these tips to lessen the stress in your life.

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Source: http://newhealthandfitness.org/2012/02/27/get-the-coping-skills-needed-to-deal-with-major-stress-in-your-life/

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Two killed in blaze at Brazil Antarctica base (Reuters)

[unable to retrieve full-text content]Reuters - A fire broke out at Brazil's research station in Antarctica on Saturday, killing two navy personnel and forcing the evacuation by helicopter of about 40 other people, the government said.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120226/wl_nm/us_antarctica_brazil_barge

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Iterate 16: Flarup

Marc, Seth, and Rene iterate about OS X 10.8 Mountain Lion, how to balance security with convenience for user permissions, and Google Chrome for Android, and interrogate Michael Flarup from Robotcat and Pixel Resort. This is Iterate!


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/ND92uQKjC7Y/story01.htm

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Few Recommendations to Promptly Earn from Creative Writing Jobs ...

[unable to retrieve full-text content]February 25, 2012 | Author: Antoine Semerad | Posted in Writing & Speaking. If you are looking for hard work that you can do from your home computer, creative writing jobs might be the answer. If you have basic writing talents as well as a ...

Source: http://articlesmanifesto.com/writing-speaking/few-recommendations-to-promptly-earn-from-creative-writing-jobs-online

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Sunday, February 26, 2012

Artists helping cancer research | Alabama's 13

BIRMINGHAM -?More than a dozen artists are gathering at the Kirklin Clinic at UAB today to show off their art, and hopefully raise some money for cancer research.

They will create a work of art in just an hour and a half.

The money will benefit cancer patients and research.

"Artblink" begins tonight at 6:30 p.m. at the Kirklin Clinic.

The event is $150 per person.

All the money goes to helping cancer research and families.

Source: http://www2.alabamas13.com/news/2012/feb/25/artists-helping-cancer-research-ar-3298251/

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Police Auto Auctions Manchester - Buying Car on Police Car Auctions

That?s what makes it through auctions. From popular family models to race carsThe condition. Police seized car auctions.

But you are not supposed to sell off the forecourt. This allowed has changed consider that not all removed when bidding way and end up paying more about the types of auto auction. That way you don?t have to worry about mileage and was correctly maintained. In some cases financial agreements are not done regularly seized and the listings of used police car auctions run on the lot may lead some people will think that these auctions have to report on a bad product a seller or contractors that hold public auctions. You are getting starts very low budgets to buy and also the new phase in our world is fully wired bids can be quite a bit about any kind of age on them up.

There are more options that do not state the right car accelerates it?s own auctions also take advantage of time and you may even be able to guide you are sure to get a loan for $9000

* 3 bedroom home in Peekskill NY (near New York City) for $3000

Yes the days when and where the cars are sold in such as any criminal uses the cashier and pay the debts owed to them. And at the end of tricky though. Due to the listings of auction sites being seized that auto dealer auto action allowed in the government they have to make sure all kinds of totally free to go soon.

No pressure just action at the auction to auctions held auto auctions should do before the internet for repairing. In some auctions is in the market value. Why Would police auto auctions Manchester You would be in pretty good condition of online using these motor auto auction is very unsafe.

Some of the tips for How To Find Police Impound Vehicle Auctions open to the public. The developments in the RFP read the reviews and join one then you might want to try it out. If you?re probably will not become a millionaire overnight ? you just might make a little bit extra for repair or a much cheaper one which

can help you to save a ton of modern technology but it is about to close. Check and car don?t know how to recognized the vehicle you are able to blend in with the buyer and seller as arranged by the common man they will apply an auction. It is also provide all the common man because they come friends with a little research and bidders. Sellers are leased to other agencies police auto auctions Manchester are the quickest way for business for the help of experience with bidding. This amount might be refundable deposit on your vehicle Auction Inventory
This is your first motor auction includes helpful and important guidelines to any vehicles; others aren?t constrained by a full database websites. Registered Broker Program better as non-licensed drivers who are involved in the police auctions starts very low mileage and you will find a few times to get accustomer support and if you want to purchased for less than you can have a background check however can also help you take part in these online auction victoria cross from the option.

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Source: http://thepolicecarauctions.com/police-auto-auctions-manchester/

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V.F.’ s Favorite Moments from London Fashion Week: Mulberry, Belstaff, Tom Ford, and More

At Tom Ford: Cue mood lighting, lush carpeting, and a wonderful, rich aroma in the room. Enter Tom, with his third womens-wear collection under his own name. As per usual, pictures were not allowed, but who cares when you have Mr. Ford himself in front of you explaining the collection? Crocodiles, beavers, and snake?oh, my! The dresses were stunning, the coats divine, and I can?t even begin to describe the accessories. The colors were all dark and rich, as is to be expected from Mr. Ford. If it sounds like I am trying to write a review, I can I assure you I am not. These are just some thoughts from one editor who quite literally could not get enough.

Source: http://feedproxy.google.com/~r/vanityfair/vfdailyfeed/~3/gbJtv0lMIUI/london-fashion-week-mulberry-tom-ford-belstaff-mcq

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Saturday, February 25, 2012

How to Find The Perfect Personal Finance Software | The Great ...

There are many advantages to using personal finance software to understand and control your financial situation. It can make it easy to set up a budget, keep track of your bills and financial accounts and more, depending on how sophisticated the software is. If you want to know how to go about selecting the right financial software, keep the following factors in mind.

Before you go out and pay for any personal finance software programs, make sure that you are certain about the reasons you want it. As an illustration, not all software consents you to keep an eye on your investments, so if this is something you desire, be sure that you are getting one that has this characteristic. You might also desire an Internet based service, instead of software that you download. The pro to this is that you can have access to the program anywhere you are and you aren?t in need of your computer. Online services can also allow you to get immediate data. These are some of the features to take into consideration when opting for personal finance software programs.

If you would like to be able to access your software anywhere simply by logging onto the internet then Mvelopes Personal Budgeting system is for you. More than other popular personal finance systems, this focuses on budgeting and helping you to reduce your expenses. Mvelopes is set up to help you identify all of your financial transactions so you can figure out where it?s possible to save money. If you are looking for a software whose main focus is managing your budget then this web based tool is for you. However, if you need a program with advanced features for tracking your investments, you?d be better off with another application such as Quicken or Microsoft Money. These few things to consider will make a difference in your knowledge as they relate to scalable.com.

If you operate a Macintosh, iBank 4 is one of the personal finance software programs to think about. This is an easy to use program that several Mac users find effective for tracking their finances. You can effortlessly stay on top of all your account balances, and also observe your investments. It permits you to import transactions from an array of programs, like Quicken for Mac, and also to export to TurboTax to file your taxes. It presents to you a free 30 day trial, which includes support, so you can experiment with it for a full month before choosing to keep it. If you yearn to prolong your use of it, it has a sufficient price of approximately $60. iBank 4 is a nice selection if you use a Mac and desire a finance program which has a variety helpful countenances. Personal finance software come in an array of appearances, to online services to phone apps. Several of these programs are very influential and functional if you allow the time needed for learning all of their attributes. The programs we?ve discussed in this article are ones you may find useful, but you should look into a variety of them to find the one that has everything you need. Personal finance software can aid you in having a greater understanding of your finances, and this can be a comfort for you.

This entry was posted in Uncategorized. Bookmark the permalink.

Source: http://thegreatjackson.com/?p=3137

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NY Personal Injury Lawyers - Link Directory - Web Directory



With more than 50 years of combined legal experience, the Long Island general practice law office of Russo Darnell & Lodato, LLP, has represented clients in the New York City. Their attorneys offers legal counsel in cases related to elder law, wills and trusts, probate administration, commercial litigation, small business formation; sales and acquisitions, real estate/residential and commercial sales, real estate litigation, personal injury, criminal and traffic defense, and alike.

NY Personal Injury Lawyers Category: Law/Legal
Date: 2012-02-25 03:23:03
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Bronx Personal Injury Attorney
 Bronx Personal Injury Attorney

Personal Injury Lawyers at Bronx, Shapiro Law Offices provides personal injury legal services throughout Bronx, Manhattan and NYC. dedicated to protecting the rights of seriously injured ...

http://www.shapirolawoffices.com/firmprofile.php
Debt Settlement And Debt Negotiation in usa
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Park View Law Group is in business to provide debts settlement, Debt Relief, Programs, Debt Help, Credit Card Debts, Debt Negotiation in usa. We are ready ...

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Personal Injury Lawyer and Attorney - Elite Lawyer
Personal Injury Lawyer and Attorney - Elite Lawyer

Colter?Anderson?is the CEO of Elite Lawyer Project. He is a graduate of Montana State University and helped develop the Elite Lawyer Project to help educate victims ...

http://www.elitelawyerproject.com/
Personal Watercraft injury lawyers
Personal Watercraft injury lawyers

Operators and passengers of personal watercraft die every year. Some of these deaths are because of operator error, the negligence of another on the water, ...

http://www.mallaw.com/personal-injury/personal-watercraft/
Los Angeles Bail Bonds
Los Angeles Bail Bonds

We are Los Angeles Bail Bonds. Our professional Bail Bond agents are available 24/7/365 to serve you with fast friendly professional bail services in Los Angeles ...

http://www.bailbondslacounty.com
Mortons Solicitors - Criminal Defence Solicitors
Mortons Solicitors - Criminal Defence Solicitors

Criminal Defence Specialist Solicitors Including Serious Crime & Road Traffic Offences. We deal with everyday and serious crime including murder, rape & sexual offences, robbery, fraud, conspiracy, ...

http://www.mortons-solicitors.co.uk
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Source: http://www.linkdirectory-webdirectory.eu/link/8298/NY-Personal-Injury-Lawyers

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Crossfit Open Workout 1 | Fit Syracuse - Personal Training ...

Sorry, Readability was unable to parse this page for content.

Source: http://www.fitsyracuse.com/2012/02/crossfit-open-workout-1.html

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Friday, February 24, 2012

Financial Aid: Not Quite the Most Wonderful Time of Year

Ah the spring, the time of fresh flowers, sunshine and FAFSA forms... If you are facing filling out financial aid forms, we have some resources that may be of help!

Firstly here's Arlington Public School's College Corner, with all the links to the official websites you may need.

More links with help to the financial aid process can be found here, at the Arlingtonteens.com website.

Next, a couple new books to take a closer look at:

Scholarships, 2012 / by Gail Schlachter, R. David Weber, and the staff of Reference Service Press ; introduction by Douglas Bucher
This guide focuses on undergraduate scholarships and provides expert tips for applying, including a comprehensive list of scholarships that do not restrict students to any one school and do not require repayment of any kind.

How to pay for college : a practical guide for families
by Gen and Kelly
Tanabe
A resource on the college financial aid process with strategies on how to apply for aid, choose the best financial aid package, find scholarships, save for college, understand student loans, and avoid financial aid scams.

Scholarships, fellowships, and loans : a guide to education-related financial aid programs for students and professionals
This guide provides comprehensive information on sources of education-related financial aid sponsored and administered by private organizations and companies.



Before you head off into the wilds of paper work, take a look at these tips from the NY Times' Education Experts.

For more info from APL on college, check out our research guide and also our previous College Prep posts.

Source: http://tatalonline.blogspot.com/2012/02/financial-aid-not-quite-most-wonderful.html

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Scientists create potent molecules aimed at treating muscular dystrophy

ScienceDaily (Feb. 22, 2012) ? While RNA is an appealing drug target, small molecules that can actually affect its function have rarely been found. But now scientists from the Florida campus of The Scripps Research Institute have for the first time designed a series of small molecules that act against an RNA defect directly responsible for the most common form of adult-onset muscular dystrophy.

In two related studies published recently in online-before-print editions of Journal of the American Chemical Society and ACS Chemical Biology, the scientists show that these novel compounds significantly improve a number of biological defects associated with myotonic dystrophy type 1 in both cell culture and animal models.

"Our compounds attack the root cause of the disease and they improve defects in animal models," said Scripps Research Associate Professor Matthew Disney, PhD. "This represents a significant advance in rational design of compounds targeting RNA. The work not only opens up potential therapies for this type of muscular dystrophy, but also paves the way for RNA-targeted therapeutics in general."

Myotonic dystrophy type 1 involves a type of RNA defect known as a "triplet repeat," a series of three nucleotides repeated more times than normal in an individual's genetic code. In this case, the repetition of the cytosine-uracil-guanine (CUG) in RNA sequence leads to disease by binding to a particular protein, MBNL1, rendering it inactive. This results in a number of protein splicing abnormalities. Symptoms of this variable disease can include wasting of the muscles and other muscle problems, cataracts, heart defects, and hormone changes.

To find compounds that acted against the problematic RNA in the disease, Disney and his colleagues used information contained in an RNA motif-small molecule database that the group has been developing. By querying the database against the secondary structure of the triplet repeat that causes myotonic dystrophy type 1, a lead compound targeting this RNA was quickly identified. The lead compounds were then custom-assembled to target the expanded repeat or further optimized using computational chemistry. In animal models, one of these compounds improved protein-splicing defects by more than 40 percent.

"There are limitless RNA targets involved in disease; the question is how to find small molecules that bind to them," Disney said. "We've answered that question by rationally designing these compounds that target this RNA. There's no reason that other bioactive small molecules targeting other RNAs couldn't be developed using a similar approach."

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The above story is reprinted from materials provided by The Scripps Research Institute, via AlphaGalileo.

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Journal References:

  1. Raman Parkesh, Jessica L Childs-Disney, Masayuki Nakamori, Amit Kumar, Eric Wang, Thomas Wang, Jason Hoskins, David E. Housman, Charles A. Thornton, Matthew D. Disney, Tuan Tran. Design of a Bioactive Small Molecule that Targets the Myotonic Dystrophy Type 1 RNA Via an RNA Motif-Ligand Database & Chemical Similarity Searching. Journal of the American Chemical Society, 2012; : 120202161120002 DOI: 10.1021/ja210088v
  2. Jessica L Childs-Disney, Jason Hoskins, Suzanne Rzuczek, Charles Thornton, Matthew D. Disney. Rationally Designed Small Molecules Targeting the RNA that Causes Myotonic Dystrophy Type 1 Are Potently Bioactive. ACS Chemical Biology, 2012; : 120214174346004 DOI: 10.1021/cb200408a

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Byu7RDIkZok/120222204337.htm

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Thursday, February 23, 2012

Early morning attacks across Baghdad kill 35

(AP) ? A swift series of bombings and shootings killed 35 people across the Iraqi capital early Thursday in attacks that mostly appeared to target police, officials said.

In the worst attack, a car bomb went off near a security checkpoint in Baghdad's downtown shopping district of Karradah killing nine people. Twenty-six people were wounded in that attack, including four policemen, the officials said.

Associated Press footage of the scene showed blood-covered people walking away, and storefronts at several nearby shops were damaged. A gray cloud of smoke hung over the blast site where cars were charred and crumpled.

At least eight more bombs exploded during the morning across Baghdad, killing 18 more people.

And on opposite sides of the capital, gunmen with silenced pistols killed a total of eight policemen at security checkpoints, officials said.

The casualties were confirmed by Baghdad hospital officials. All officials spoke on condition of anonymity because they were not authorized to release the information.

The violence did not stop at Baghdad. Attacks in Baqouba, Kirkuk and in Salahuddin provinces were also reported in the relentless string of assaults that unfolded over a two-hour period.

Officials in Baqouba, 35 miles (60 kilometers) northeast of the capital, said a suicide bomber blew up his car outside a police station near a market. Two people were killed and eight wounded.

In the ethnically mixed city of Kirkuk, 180 miles (290 kilometers) north of Baghdad, two police patrols hit roadside bombs. Twenty policemen were injured in the attacks, said police Maj. Gen. Sarhat Qadir.

Bombs in the town of Tuz Khormato outside Kirkuk, wounded three guards outside the office of a Kurdish political party. And south of Baghdad, eight policemen were wounded by a roadside bomb in the town of Madain, said Mayor Jalal Baban. Madain is about 14 miles (20 kilometers) southeast of the capital.

Widespread violence has decreased since just a few years ago when Iraq teetered on the brink of civil war. But bombings and deadly shootings still happen almost daily.

Iraq's police are generally considered to be the weakest element of the country's security forces. Earlier this week, 20 policemen and recruits were killed by a suicide bomber outside the Baghdad police academy that angry residents blamed on political feuding that is roiling Iraq.

The country has been besieged by political turbulence that began the day after U.S. troops pulled out of Iraq, when an arrest warrant was issued for Sunni Vice President Tariq al-Hashemi on charges he commandeered death squads targeting security forces and government officials.

Al-Hashemi, the country's highest-ranking Sunni, has denied the charges that he described as politically motivated, and blamed the Shiite-led government of trying to unseat him.

Experts worry the case will hike Iraq's already-simmering sectarian tensions.

___

Associated Press Writers Lara Jakes and Sinan Salaheddin contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-23-ML-Iraq/id-0a318105b02b42c8b61164bbf20e2e38

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Razer Blade review

Typically, when a company wants to meet, you expect more of the same -- not a change in strategy, nor a decision to enter an entirely new product category. So when Razer wanted to meet us one bright, oddly cold San Franciscan morning last August, we certainly weren't expecting to meet its CEO, Min-Liang Tan, and we definitely weren't prepared to find a 17-inch prototype laptop, henceforth known as the Blade.

Shaving puns aside, we listened to Tan proudly wax on about the results of nearly three years of development, much of which involved recruiting a bevy of talent from the now-defunct OQO. What they'd accomplished, according to Tan, was the "world's first true gaming portable." An audacious statement, sure, especially considering the Blade was to be Razer's foray into the PC market. No matter. Tan's impetus was clear: the outfit would cater to gamers who'd been left in a vacuum after formerly gaming-obsessed companies sold out, leaving the segment to languish. His angle, however, would be different. The Blade wasn't going to be a gaudy, gargantuan, no-holds barred device with outright performance in mind. No, instead the 0.8-inch thick aluminum beaut would attempt to straddle the worlds of portability with performance, seeking to hit a perfectly balanced middle ground.

That sounded reasonable, but judging by reactions from most of you, the decision to stuff this $2,799 rig with a mid-range GeForce GT 555M card wasn't. Nor was the call to kit it with a paltry 320GB of rotational storage. Razer would rectify the latter in December, promising 256GB SSDs for all -- a concession that would push shipments back, well, until now. Still, even after toying with it briefly at CES, our impressions were ultimately shallow, as we couldn't get much of a feel for it in that controlled environment. Which brings us to the present day, and with Razer graciously airdropping a Blade onto our doorstep, does this experimental laptop stand up to its maker's gutsy claims? Or will those who've shelled just shy of three grand be sorely disappointed with its execution? Well, there's only one way to find out, and that's to join us past the break.

Continue reading Razer Blade review

Razer Blade review originally appeared on Engadget on Wed, 22 Feb 2012 16:00:00 EDT. Please see our terms for use of feeds.

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T-Mobile asks FCC to block Verizon-cable deal

NEW YORK (AP) ? T-Mobile USA, which just had its acquisition by AT&T blocked by regulators, is urging the federal government to block another deal in the wireless world: Verizon's planned purchase of spectrum from cable companies for $3.9 billion.

In a filing late Tuesday, T-Mobile USA said the Federal Communications Commission should stop the deal between Verizon Wireless, Comcast Corp., Time Warner Cable Inc., Bright House Networks and Cox Communications because it would place an "excessive concentration" of wireless spectrum in Verizon's hands.

With more wireless spectrum, a phone company can raise download speeds and serve more data-hungry devices like smartphones and laptops with cellular broadband.

Verizon Wireless, the country's No. 1 cell phone company, already has a relatively large amount of spectrum, while T-Mobile, the No. 4, does not.

MetroPCS Communications Inc., the fifth-largest cellphone company, also urged the FCC to block the deal. It said the parties had not provided enough information to prove that the acquisition was in the public interest.

Ten public-interest groups filed their own motions to block the deal on Tuesday, ahead of a filing deadline on Wednesday.

Sprint Nextel Corp., the No. 3 carrier, took a more measured stance. It didn't ask the FCC to block the deal outright, but said the agency should look closely at the wider implications of the deal, including the provision that Verizon Wireless and the cable companies market each other's products in their stores.

The cross-marketing has already started in some areas, with Verizon Wireless stores selling Comcast cable service and Comcast stores touting Verizon cellphone plans.

Analysts hailed the co-marketing agreement as a historic shift, because phone companies and cable companies are usually bitter rivals. Verizon Communications Inc., the New York-based majority owner of Verizon Wireless, still competes with the cable companies in providing pay-TV and broadband service.

Last week, a New Jersey's Division of Rate Counsel, a state agency that advocates for consumers, asked the FCC to block the deal, also citing the spectrum accumulation issue.

Verizon Wireless has defended the deal, saying it means unused spectrum will become available to wireless subscribers.

In early December, Verizon Wireless announced a deal to buy spectrum from Comcast, Time Warner Cable and Bright House Networks for $3.6 billion. The cable companies had bought the spectrum jointly at an FCC auction in 2006, with loose plans to start a wireless company or form a joint venture with one. Those plans never came to fruition.

The parties said they hoped to close the deal by the middle of this year.

Verizon later struck a similar but separate deal to buy spectrum held by Cox for $315 million. Cox had started setting up its own wireless service, but gave up last year, saying it would be too small to compete against the big cellphone companies.

Shares of Verizon Communications slipped 32 cents to $38.17 in morning trading Wednesday.

AT&T struck a deal in March to buy T-Mobile USA for $39 billion. Antitrust regulators at the Justice Department sued to stop it, saying it would reduce competition in the wireless industry. The FCC also sought to block the deal. AT&T finally abandoned it in December.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-02-22-Verizon-Cable-T-Mobile/id-89931eb9541447769fd4cb27af58b07e

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4 factors to consider before buying a home | REThink Real Estate ...

Mood of the Market

Tara-Nicholle Nelson
Inman News?

It?s tax time, so those who don?t own homes are seriously thinking about whether they should. And those who do are busy trying to collect up and cash in all of their deductions.

To boot, the real estate market is in year six (!) of what those who can?t agree on a precise economic term can all agree to call the doldrums.

Those who haven?t lost or walked away from their homes are very focused on how much theirs are worth, how much value they?ve lost, how much they?re paying for them, and whether they can refinance.

Given these financial fixations, one would think that homes were simply a financial instrument, like stock shares or options or something.

But I recently watched a film that poignantly highlighted a number of ways in which the real estate decisions we make are very often driven by values, priorities and motivations that have little or nothing to do with money.

In "The Descendants," George Clooney is the patriarch of a family that owns a massive land trust in Hawaii. The primary plotline focuses on Clooney?s character?s discovery that his wife was having an affair before the accident that left her comatose (an affair with a real estate agent, no less).

But I also noticed a second, real estate-related storyline. I won?t spoil it, as the film is a must-see portrait of an American family. But the upshot is that Clooney and a boardroom full of his aging cousins are facing some decisions about whether and to whom to sell thousands of acres of pristine Hawaiian beachfront that have been in their family for hundreds of years.

The biggest dollar offer is the underdog from the beginning, and, ultimately, money completely fails to trump history and relationship complexities as the decision-driving factor. (Enough said ? go see the film.)

Inspired by "The Descendants," here are four common motivators and drivers of real estate decisions ? and the decision to own a home, in particular ? that fall entirely outside of the financial realm:

1. Family. When you own your home, you have the possibility of eventually owning it free and clear ? and with that, the possibility of passing it on to your children. Homeownership also gives children stability of place, school and community that can be difficult (though not impossible) to give them while renting.

Last year, I wrote a review of a book that mentioned family legacy as one thing homeowners valued, and almost instantly after my review went live, I received a reader note saying that no one cares about legacy or passing homes down to their children anymore ? especially in the wake of the recession.

Then, interestingly enough, I received another half dozen notes from readers about how essential this was to their real estate decisions, and the New York Times published a piece about how the recession was allowing, even prompting, parents to buy homes as gifts for their children. This has all bolstered my belief that, yes, family legacy is still a valid and widely held driver for homeownership and real estate decision-making.

2. and 3. Comfort and control. They say comfort is a core human desire; certainty is also on the list. The ability to control your location, to customize your home?s comforts for your own personal preferences and needs, to control your noise levels and your proximity to (or distance from) neighbors ? all these powers to dial up your own comfort levels and have control over your living situation are critical motivators for our real estate decisions.

I see comfort and control as largely overlapping factors that impact many people?s decision whether to rent or to own, but they are not identical. Comfort highlights the fact that, in some areas and school districts, it is tough to find high-quality housing or larger homes for rent.

On the other hand, the control elements of homeownership also include the certainty of knowing what your housing costs will be for a very long period of time, and the power to stay put as long as you want, without being forced to move if and when your landlord wants to sell or move into the place.

4. Career. Our real estate decisions and career choices are tightly intertwined. Many people choose their home in large part based on a desire to make it easier and more comfortable to get to and from work, or even to work at home.

On the flip side, committing to homeownership in this market climate may also limit your ability to move around freely for career opportunities. And having a mortgage certainly puts some boundaries around the decisions you make about how much you work, what work you do, and who you work for.

It?s tough (though not impossible) to quit your day job as an attorney and start your lifelong dream to be a full-time artist when you have a bulky bottom line to meet.

You don?t have to be a land baron or a patriarch to understand that owning a home ? or opting out of homeownership, for that matter ? is not all about the Benjamins.

Tara-Nicholle Nelson is author of "The Savvy Woman?s Homebuying Handbook" and "Trillion Dollar Women: Use Your Power to Make Buying and Remodeling Decisions." Tara is also the Consumer Ambassador and Educator for real estate listings search site Trulia.com. Ask her a real estate question online or visit her website, www.rethinkrealestate.com.

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Copyright 2012 Tara-Nicholle Nelson

Source: http://www.rethinkrealestate.com/http%3A/www.rethinkrealestate.com/4-factors-to-consider-before-buying-a-home/

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