Th? small joint ?t th? base ?f th? b?g toe ?? th? m??t common site ?f ?n acute gout attack ?f arthritis. An acute attack ?f gouty arthritis ?t th? base ?f th? b?g toe ?? medically referred t? ?? podagra. Oth?r joints th?t ?r? commonly affected include th? ankles, knees, wrists, fingers, ?nd elbows. Acute gout attacks ?r? characterized b? a rapid onset ?f pain ?n th? affected joint followed b? warmth, swelling, reddish discoloration, ?nd m?rk?d tenderness. Tenderness ??n b? intense ?? th?t even a blanket touching th? skin over th? affected joint ??n b? unbearable. Patients ??n develop fever w?th th? acute gout attacks. Th??? painful attacks usually subside ?n hours t? days, w?th ?r without medication. In rare instances, ?n attack ??n last f?r weeks. M??t patients w?th gout w?ll experience repeated attacks ?f arthritis over th? years.
Uric acid crystals ??n deposit ?n t?n? fluid-filled sacs (bursae) around th? joints. Th??? urate crystals ??n incite inflammation ?n th? bursae, leading t? pain ?nd swelling around th? joints (a condition called?bursitis). In rare instances, gout leads t? a more chronic type ?f joint inflammation th?t mimics?rheumatoid arthritis.
In chronic (tophaceous) gout, nodular masses ?f uric acid crystals (tophi) deposit ?n different soft-tissue areas ?f th? body. Even though th?? ?r? m??t commonly found ?? hard nodules around th? fingers, ?t th? tips ?f th? elbows, ?n th? ears, ?nd around th? b?g toe, tophi nodules ??n appear anywhere ?n th? body. Th?? h??? b??n reported ?n unexpected areas such ?? ?n th? vocal cords ?r (rarely) even around th? spinal cord. Wh?n tophi appear ?n th? tissues, th? gout condition ?? felt t? represent a substantial overload ?f uric acid within th? body.
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